World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website http://www.wjon.org

Case Report

Volume 8, Number 2, April 2017, pages 58-61


Repeated Multiple Neurofibromatosis Type 1 in the Right Lower Limb: A Case Report

Figures

Figure 1.
Figure 1. (a) A computed tomography image showing multiple masses with homogeneous density and no bone destruction, with a maximum size of 7.0 × 6.1 cm. (b) A T2-weighted magnetic resonance imaging scan showing a higher signal intensity, with the mass showing an uneven signal and well-defined margins. (c) A T1-weighted magnetic resonance imaging scan showing a slightly higher signal intensity, with the mass showing an uneven signal and liquefaction at the center.
Figure 2.
Figure 2. Histological observations. (a) The largest excised specimen was dark gray and measured 7 × 6.5 × 4.5 cm. (b) Photomicrograph of the neurofibroma component showed papillary proliferation of cells with cystic degeneration and a lobular arrangement (hematoxylin-eosin staining; magnification, × 100). (c) The neurofibroma was composed of proliferating spindle cells containing bland cigar-shaped nuclei with inconspicuous nucleoli and an eosinophilic cytoplasm. The lobules in the masses comprised a tight swirl of cells, though the focal areas demonstrated closely clustered thin-spindled and stellate cells (hematoxylin-eosin staining; × 100).