World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website http://www.wjon.org

Letter to the Editor

Volume 9, Number 2, April 2018, pages 66-67

Concomitant ATM Mutations Identified by Next Generation Sequencing in a Patient With New-Onset Acute Myeloid Leukemia Following Imatinib Treatment for Chronic Myeloid Leukemia

Table

**Table 1.** *In Silico* Analysis of VUS Identified by NGS of Bone-Marrow Cells in a CML Patient with *BCR/*ABL-negative AML
Gene	VUS	Polyphen-2 score	Prediction
ARID1A	R1593W	0.893 (sensitivity, 0.70; specificity, 0.90)	Possibly damaging
ARID2	T749I	0.001 (sensitivity, 0.99; specificity, 0.09)	Benign
ATM	G2863V	1.000 (sensitivity, 0.00; specificity, 1.00)	Probably damaging
MKI67	Q689R	0.004 (sensitivity, 0.98; specificity, 0.35)	Benign
MYO18A	I1723V	0.011 (sensitivity, 0.96; specificity, 0.51)	Benign
NCSTN	P322S	0.018 (sensitivity, 0.95; specificity, 0.55)	Benign