World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website http://www.wjon.org

Original Article

Volume 9, Number 3, June 2018, pages 80-84

Major Risk Factors in Head and Neck Cancer: A Retrospective Analysis of 12-Year Experiences

Figure 1. Relationship between “smokers”, “alcoholics”, “alcoholics and smokers” and “total HNC patients” represented through Venn diagram.

**Table 1.** Clinical Presentation of HNC Patients (n = 9,950)
Sr. no.	Clinical presentation	Total number of patients (n = 9,950)	Percentage of patients (%)
1	Bleeding from mouth	63	0.63
2	Hoarseness of voice	944	9.48
3	Dysphagia	3,655	36.7
4	Odynophagia	1,876	18.9
5	Ulcerative growth in mouth	585	5.87
6	Throat pain	343	3.44
7	Neck/cervical swelling	1,843	18.5
8	Dyspnea	160	1.60
9	Trismus	185	1.85
10	Headache/earache	232	2.33
11	Nasal obstruction/discharge	64	0.64

Table 1. Clinical Presentation of HNC Patients (n = 9,950)

Sr. no.

Clinical presentation

Total number of patients (n = 9,950)

Percentage of patients (%)

Bleeding from mouth

0.63

Hoarseness of voice

944

9.48

Dysphagia

3,655

36.7

Odynophagia

1,876

18.9

Ulcerative growth in mouth

585

5.87

Throat pain

343

3.44

Neck/cervical swelling

1,843

18.5

Dyspnea

160

1.60

Trismus

185

1.85

Headache/earache

232

2.33

Nasal obstruction/discharge

0.64

**Table 2.** Age-Wise Distribution of HNC Patients (n = 9,950)
Age groups (years)	Number of HNC patients	Percentage of patients (%)
< 20	40	0.4
21 - 30	241	2.4
31 - 40	1,127	11.3
41 - 50	2,783	27.9
51 - 60	3,091	31
61 - 70	2,055	20.6
> 70	613	6.2

Table 2. Age-Wise Distribution of HNC Patients (n = 9,950)

Age groups (years)

Number of HNC patients

Percentage of patients (%)

< 20

0.4

21 - 30

241

2.4

31 - 40

1,127

11.3

41 - 50

2,783

27.9

51 - 60

3,091

61 - 70

2,055

20.6

> 70

613

6.2

**Table 3.** Stage-Wise Distribution of HNC Patients (n = 9,950)
Stage-wise distribution	Number of HNC patients	Percentage of patients (%)
Stage I	180	1.8
Stage II	591	5.9
Stage III	2,844	28.6
Stage IV	6,335	63.7

Table 3. Stage-Wise Distribution of HNC Patients (n = 9,950)

Stage-wise distribution

Number of HNC patients

Percentage of patients (%)

Stage I

180

1.8

Stage II

591

5.9

Stage III

2,844

28.6

Stage IV

6,335

63.7

**Table 4.** Smoker and Alcoholic Population With Different HNC Subtypes (n = 9,950)
Sr. no.	HNC subtype	Number of smokers (n, %)	Patient with NED status at last follow-up (smoker group)	Number of alcoholics (n, %)	Patient with NED status at last follow-up (alcoholic group)
1.	Oral Cavity (lower lip, tongue, floor of mouth, gingiva, palate, retromolar trigone, upper lip and buccal mucosa)	937 (10.6%)	151	762 (7.6%)	101
2.	Oropharynx	(Soft palate and lateral, posterior pharyngeal wall except base tongue and tonsil)	263 (2.96%)	41	92 (0.9%)	8
		Base tongue	3,454 (39%)	469	2,302 (23%)	313
		Tonsil	1,629 (18.4%)	279	1,075 (11%)	163
3.	Nasopharynx	55 (0.62%)	8	33 (0.3%)	5
4.	Hypopharynx	Post-cricoid	445 (5.0%)	64	251 (2.5%)	43
		Pyriform fossa	312 (35.2%)	59	226 (2.3%)	33
5.	Larynx	Supraglottic	947 (10.7%)	269	907 (9%)	197
		AE fold	81 (0.9%	28	23 (0.2%)	9
		Epiglottis	287 (3.2%)	43	58 (0.6%)	17
		Vocal cord	947 (10.7%)	269	31 (0.3%)	11
6.	Sinonasal (maxilla, nasal cavity)	115 (1.2%)	11	51 (0.5%)	4
7.	Salivary gland	80 (0.9%)	14	43 (0.4%)	6
8.	EAC	12 (1.13%)	1	7 (0.1%)	0
	Total alcoholic patients (out of total HNC patients, n = 9,950)	8,859 (89%)	1,706	5,861 (59%)	910

Table 4. Smoker and Alcoholic Population With Different HNC Subtypes (n = 9,950)

Sr. no.

HNC subtype

Number of smokers (n, %)

Patient with NED status at last follow-up (smoker group)

Number of alcoholics (n, %)

Patient with NED status at last follow-up (alcoholic group)

Oral Cavity (lower lip, tongue, floor of mouth, gingiva, palate, retromolar trigone, upper lip and buccal mucosa)

937 (10.6%)

151

762 (7.6%)

101

Oropharynx

(Soft palate and lateral, posterior pharyngeal wall except base tongue and tonsil)

263 (2.96%)

92 (0.9%)

Base tongue

3,454 (39%)

469

2,302 (23%)

313

Tonsil

1,629 (18.4%)

279

1,075 (11%)

163

Nasopharynx

55 (0.62%)

33 (0.3%)

Hypopharynx

Post-cricoid

445 (5.0%)

251 (2.5%)

Pyriform fossa

312 (35.2%)

226 (2.3%)

Larynx

Supraglottic

947 (10.7%)

269

907 (9%)

197

AE fold

81 (0.9%

23 (0.2%)

Epiglottis

287 (3.2%)

58 (0.6%)

Vocal cord

947 (10.7%)

269

31 (0.3%)

Sinonasal (maxilla, nasal cavity)

115 (1.2%)

51 (0.5%)

Salivary gland

80 (0.9%)

43 (0.4%)

EAC

12 (1.13%)

7 (0.1%)

Total alcoholic patients (out of total HNC patients, n = 9,950)

8,859 (89%)

1,706

5,861 (59%)

910