World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website http://www.wjon.org

Original Article

Volume 9, Number 3, June 2018, pages 74-79

Analysis of Risk Factors for Lymphatic Metastasis in Endometrial Carcinoma and Utility of Three-Dimensional Magnetic Resonance Imaging in Gynecology

Figures

Figure 1. Using 3D-MRI reconstructions complete visualization of the pelvis is possible.

Figure 2. The border of tumors is outlined and the outlined tumors are cored out, integrated, and the tumor volume is automatically calculated using the volumetry function.

Figure 3. Receiver operating curve to determine potential values of tumor volume for prediction of lymphatic metastasis.

Figure 4. Receiver operating curve to determine potential values of CA125 level for prediction of lymphatic metastasis.

Tables

**Table 1.** Clinicopathologic Features of 59 Patients With Endometrial Adenocarcinoma
Factor		No.	%
Age (years)
Mean ± SD	61.6 ± 7.7
≥ 60		34	57.6
< 60		25	42.4
Histologic type (preoperative)
G1		28	47.5
G2		11	18.6
G3		5	8.5
Others		15	25.4
Myometrial invasion (MRI)
≥ 1/2		25	42.4
< 1/2		34	57.6
CA125 (IU/L)
Mean ± SD	51.6 ± 135.3
≥ 29		20	33.2
< 29		39	66.1
Tumor volume (cm³)
Mean ± SD	11.6 ± 18.4
≥ 12.79		27	45.8
< 12.79		32	54.2
Lymphatic metastasis
positive		10	16.9
negative		49	83.1

**Table 2.** Evaluation of Histologic Grade
		Postoperative histologic grade
		G1	G2	G3	Others
Preoperative histologic grade	G1	22	4	0	2
	G2	1	9	1	0
	G3	0	0	5	0
	Others	1	1	2	11

**Table 3.** Evaluation of Myometrial Invasion
		Myometrial invasion by pathology
MRI based myometrial invasion		< 1/2	≥ 1/2
	< 1/2	29	5
	≥ 1/2	2	23

**Table 4.** Correlation Between the Preoperative Risk Factors and Lymphatic Metastasis
Preoperative risk factor	Univariate*	Multivariate*
Preoperative risk factor	P value	Hazard ratio	95% Confidence interval	P value
*Logistic regression analysis.
Age (< 60, ≥ 60) (ys)	0.49	1.27	0.21 - 7.59	0.79
CA125 (< 29, ≥ 29) (IU/L)	0.011	3.57	0.49 - 26	0.21
Tumor volume (< 12.79, ≥ 12.79) (cm³)	0.012	12.7	1.06 - 154	0.04
Histologic type (G1-2, G3-others)	0.31	5.54	0.78 - 39.4	0.08
Myometrial invasion (< 1/2, ≥ 1/2)	0.17	2.14	0.36 - 12.5	0.39