| World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc |
| Journal website http://www.wjon.org |
Original Article
Volume 9, Number 3, June 2018, pages 69-73
Failure of Ploidy and Proliferative Fraction to Predict Long-Term Outcome After Prostatectomy
Tables
| Number | Mean | Med | Range | |
|---|---|---|---|---|
| LN: lymph nodes; SV: seminal vesicles; EPE: extraprostatic extension; Mar: margins. | ||||
| Age at surgery | 127 | 66 yrs | 67 yrs | 47 - 83 |
| Preoperative PSA | 121 | 10.4 ng/mL | 10.3 ng/mL | 1.4 - 54.6 |
| S phase | 106 | 8.2% | 6.6% | 0.8 - 33.0 |
| Gleason | ||||
| < 7 | 59 | |||
| 7 | 59 | |||
| > 7 | 9 | |||
| Ploidy | ||||
| Diploid | 107 | |||
| Aneuploid | 20 | |||
| Pathology findings | ||||
| LN+ | 10 | |||
| SV+ | 21 | |||
| EPE+ | 38 | |||
| Mar+ | 30 | |||
| Gleason < 7 (%) | Gleason 7 (%) | Gleason > 7 (%) | P value | PSA < 10 (%) | PSA > 10 (%) | P value | |
|---|---|---|---|---|---|---|---|
| ¶P-value was calculated by Mantel-Haenszel Chi-square test. £P-value was calculated by Fisher’ exact Chi-square test. ±P-value was calculated by Pearson Chi-square test. | |||||||
| Diploid | 51 (48%) | 47 (44%) | 9 (8%) | 0.348¶ | 78 (73%) | 29 (27%) | 0.472£ |
| Non-diploid | 8 (40%) | 12 (60%) | 0 | 13 (65%) | 7 (35%) | ||
| S phase < 6.6% | 37 (50%) | 31(42%) | 6 (8%) | 0.483¶ | 52 (70%) | 22 (30%) | 0.682± |
| S phase > 6.6% | 22 (42%) | 28 (53%) | 3 (6%) | 39 (74%) | 14 (26%) | ||
| Biochemical failure£ | PC death¶ | ||||
|---|---|---|---|---|---|
| Factor | Number | Failed # | Failed % | P-value | P-value |
| £P-values were calculated by Pearson Chi-square test or Mantel-Haenszel Chi-square test. When at least one cell that expected count less than 5, Fisher’s exact test was implemented. ¶PC death is the death caused by prostate cancer. P values were calculated with the use of Cox proportional-hazards models. | |||||
| Diploid | 107 | 51 | 48% | 0.8266 | 0.1709 |
| Non diploid | 20 | 9 | 45% | ||
| S phase ≤ 6.6% | 74 | 30 | 41% | 0.0738 | 0.8400 |
| S phase > 6.6% | 53 | 30 | 57% | ||
| EPE+ | 38 | 28 | 74% | < 0.0001 | 0.0749 |
| EPE- | 88 | 31 | 35% | ||
| Mar+ | 30 | 21 | 70% | 0.0036 | 0.3868 |
| Mar- | 96 | 38 | 40% | ||
| SV+ | 21 | 15 | 71% | 0.0167 | 0.2033 |
| SV- | 105 | 44 | 42% | ||
| LN+ | 10 | 9 | 90% | 0.0063 | 0.6428 |
| LN- | 117 | 51 | 44% | ||
| Gleason < 7 | 59 | 19 | 32% | 0.0008 | 0.0023 |
| Gleason 7 | 59 | 33 | 56% | ||
| Gleason > 7 | 9 | 8 | 89% | ||
| PSA < 10 | 91 | 34 | 37% | 0.0004 | 0.5478 |
| PSA > 10 | 36 | 26 | 72% | ||