| World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc |
| Journal website http://www.wjon.org |
Original Article
Volume 9, Number 3, June 2018, pages 91-95
Comparison of Single Versus Multifraction Radiotherapy in Palliation of Painful Bone Metastases
Tables
| Characteristics | Group I (n = 20) | Group II (n = 20) | Group III (n = 20) | ||||
|---|---|---|---|---|---|---|---|
| Mean age/range (years) | 58.6/ 45 - 75 | 60.5/35 - 82 | 56.5/37 - 74 | ||||
| Number of patients | Percentage | Number of patients | Percentage | Number of patients | Percentage | ||
| Gender | Male | 14 | 70 | 13 | 65 | 15 | 75 |
| Female | 6 | 30 | 7 | 35 | 5 | 25 | |
| Rural/urban status | Rural | 14 | 70 | 13 | 65 | 14 | 70 |
| Urban | 6 | 30 | 7 | 35 | 6 | 30 | |
| Karnofsky performance status ≥ 60 | 14 | 70 | 12 | 60 | 12 | 60 | |
| Site of primary | Prostate | 10 | 50 | 7 | 35 | 4 | 20 |
| Breast | 5 | 25 | 3 | 15 | 1 | 5 | |
| Lung | 3 | 15 | 1 | 5 | 5 | 25 | |
| MUO | 1 | 5 | 2 | 10 | 8 | 40 | |
| Others | 1 | 5 | 7 | 35 | 2 | 10 | |
| Site of bone metastases | Multiple | 8 | 40 | 7 | 35 | 3 | 15 |
| Spine | 6 | 30 | 8 | 40 | 10 | 50 | |
| Pelvis | 3 | 15 | 4 | 20 | 3 | 15 | |
| Sternum | 1 | 5 | 1 | 5 | 4 | 20 | |
| Axial skeleton | 2 | 10 | 0 | 0 | 0 | 0 | |
| Site of palliative radiotherapy | Spine | 8 | 40 | 9 | 45 | 10 | 50 |
| Pelvis | 8 | 40 | 8 | 40 | 5 | 25 | |
| Others | 4 | 20 | 3 | 15 | 5 | 25 | |
| Group I (n = 20) | Group II (n = 20) | Group III (n = 20) | ||||
|---|---|---|---|---|---|---|
| Number of patients | Percentage | Number of patients | Percentage | Number of patients | Percentage | |
| Complete pain response | 4 | 20 | 4 | 20 | 4 | 20 |
| Overall pain response | 16 | 80 | 15 | 75 | 17 | 85 |
| Minimum mean pain score | 31.5 | - | 37.8 | - | 31.6 | - |
| Improved performance status | 2 | 10 | 4 | 20 | 2 | 10 |
| Decreased analgesic requirement | 13 | 65 | 13 | 65 | 13 | 65 |
| Mean duration of pain relief | 23.5weeks | - | 22.6 weeks | - | 21.9 weeks | - |
| Re-irradiation | 4 | 20 | 1 | 5 | 0 | 0 |
| Group I | Group II | Group III | |
|---|---|---|---|
| Average distance travelled per day for radiation treatment (i.e. from home to treatment center and back) | 101 km | 102.4 km | 97 km |
| Number of radiation treatment days | 1 | 5 | 10 |
| Average distance travelled from home to treatment center for complete radiation treatment | 101 km | 512 km | 970 km |
| Total expenditure on travel during radiation treatment considering average cost of travel at Rs 10/km | Rs 1,010 per patient | Rs 5,120 per patient | Rs 9,700 per patient |
| Study | Complete pain relief | Overall pain relief | Retreatment | |
|---|---|---|---|---|
| Bone Trial Working Party Study Group (1999) [14] | 8 Gy single fraction | 57% | 78% | 23% |
| 20 Gy/5 Fr or 30 Gy/10 Fr | 58% | 78% | 10% | |
| Hartsell et al (2005) [17] | 8 Gy single fraction | 15% | 65% | 18% |
| 30 Gy/10 Fr | 18% | 66% | 9% | |
| Roos et al (2005) [18] | 8 Gy single fraction | 26% | 53% | 1% |
| 20 Gy/5 Fr | 27% | 61% | 0 | |
| Arnalot et al (2008) [19] | 8 Gy single fraction | 15% | 75% | 28% |
| 30 Gy/10 Fr | 13% | 86% | 2% | |
| Anter et al (2015) [20] | 8 Gy single fraction | 18% | 75% | - |
| 20 Gy/5 Fr | 22% | 75% | - | |