World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website http://www.wjon.org

Original Article

Volume 9, Number 4, August 2018, pages 97-103

Age-Related Chromosomal Aberrations in Patients with Diffuse Large B-Cell Lymphoma: An In Silico Approach

Figure 1. Age-based proportions of significant aberrations. Ten significant data points were obtained. The t(2;3) translocation showed a significant increase in the proportion of patients less than 30. Similar findings were observed in trisomy 14, monosomy 3 and monosomy 11. Older patients (> 71 years) showed increased incidence of the additions of 19p13, 18q21, trisomy 3, trisomy 16 and trisomy 18.

Figure 2. Kaplan-Meier curve of age-based aberrations. The 10 significant aberrations did not show any significant differences from one another (log-rank test, P = 0.7512, Gahen-Breslow-Wilcoxon test, P = 0.8759). The poorest overall survival occurred in patients with the addition of 19p13 (7m) and trisomy 16 (9m). Superior survival occurred in those patients in trisomy 14 (25m), monosomy 11 (21m), trisomy 3 (19m) and trisomy 7 (19m).

**Table 1.** Overview of Patient Characteristics
	Overall	t2;3	Trisomy 19p13	Trisomy 18q21	Trisomy 3*	Trisomy 7	Trisomy 14	Trisomy 16	Trisomy 18	Monosomy 3	Monosomy 11
In total, 749 DLBCL patients were studied. Of these, there are 391 men and 358 women (male/female ratio: 1.09), with median age of 62 years. Values for chromosome number and karyotype complexity are displayed as mean ± standard deviation. A full summary of patient characteristics is summarized, listed by chromosomal aberrations which were found to be significant. Ten aberrations in total were found to have significant age-related differences. There were no significant differences in sex for each of these aberrations, though trisomy 19p13 showed a male predominance (75% male, P = 0.06). The median year of publication for the dataset was 2000, with a range between 1990 and 2016.
Patients	749	15	16	15	91	119	20	33	110	32	30
Men	391	8	12	9	43	57	11	17	54	14	19
Women	358	7	4	6	48	62	9	16	55	18	11
Median age (years)	62	40	73	56	67	64	58.5	68	68	56	53
0 - 30	83 (11.1)	6 (40)	0 (0)	3 (20)	3 (3.3)	4 (3.4)	6 (30)	0 (0)	5 (4.5)	9 (28.1)	11 (36.7)
31 - 50	118 (15.8)	3 (20)	1 (6.3)	1 (6.7)	12 (13.2)	22 (18.5)	3 (15)	2 (6.1)	16 (14.5)	4 (12.5)	3 (10)
51 – 70	346 (46.2)	5 (33.3)	5 (31.3)	11 (73.3)	42 (46.2)	58 (48.7)	8 (40)	19 (57.6)	41 (37.3)	12 (37.5)	11 (36.7)
71 and over	203 (27.1)	1 (6.7)	10 (62.5)	0 (0)	34 (37.4)	35 (29.4)	3 (15)	12 (36.4)	48 (43.6)	7 (21.9)	5 (16.7)
Chromosome number (mean)	59.8 ± 17.8	47.3 ± 1.9	68.7 ± 19.2	46.5 ± 3.5	55.4 ± 15.0	61.5 ± 15.8	62.5 ± 17.6	71.8 ± 17.8	56.3 ± 16.9	68.9 ± 16.8	74.2 ± 18.7
Karyotype Complexity	8.6 ± 6.4	11.1± 7.3	13.5 ± 10.3	10.7 ± 7.2	10.3 ± 5.5	11.7 ± 7.1	12.8 ± 7.5	12.5 ± 7.6	10.8 ± 7.3	17.3 ± 7.3	18.8 ± 9.1
Median year of publication	2000	2004	2006	2004	1999	2004	1999	1999	1999	2004	2003
Median survival (months)	14	10	7	17	19	19	25	9	15	15	21
P value	-	0.002	0.01	0.04	0.02	0.03	0.05	0.05	< 0.001	0.02	< 0.001

Table 1. Overview of Patient Characteristics

Overall

t2;3

Trisomy 19p13

Trisomy 18q21

Trisomy 3*

Trisomy 7

Trisomy 14

Trisomy 16

Trisomy 18

Monosomy 3

Monosomy 11

In total, 749 DLBCL patients were studied. Of these, there are 391 men and 358 women (male/female ratio: 1.09), with median age of 62 years. Values for chromosome number and karyotype complexity are displayed as mean ± standard deviation. A full summary of patient characteristics is summarized, listed by chromosomal aberrations which were found to be significant. Ten aberrations in total were found to have significant age-related differences. There were no significant differences in sex for each of these aberrations, though trisomy 19p13 showed a male predominance (75% male, P = 0.06). The median year of publication for the dataset was 2000, with a range between 1990 and 2016.

Patients

749

119

110

Men

391

Women

358

Median age (years)

58.5

0 - 30

83 (11.1)

6 (40)

0 (0)

3 (20)

3 (3.3)

4 (3.4)

6 (30)

0 (0)

5 (4.5)

9 (28.1)

11 (36.7)

31 - 50

118 (15.8)

3 (20)

1 (6.3)

1 (6.7)

12 (13.2)

22 (18.5)

3 (15)

2 (6.1)

16 (14.5)

4 (12.5)

3 (10)

51 – 70

346 (46.2)

5 (33.3)

5 (31.3)

11 (73.3)

42 (46.2)

58 (48.7)

8 (40)

19 (57.6)

41 (37.3)

12 (37.5)

11 (36.7)

71 and over

203 (27.1)

1 (6.7)

10 (62.5)

0 (0)

34 (37.4)

35 (29.4)

3 (15)

12 (36.4)

48 (43.6)

7 (21.9)

5 (16.7)

Chromosome number (mean)

59.8 ± 17.8

47.3 ± 1.9

68.7 ± 19.2

46.5 ± 3.5

55.4 ± 15.0

61.5 ± 15.8

62.5 ± 17.6

71.8 ± 17.8

56.3 ± 16.9

68.9 ± 16.8

74.2 ± 18.7

Karyotype Complexity

8.6 ± 6.4

11.1± 7.3

13.5 ± 10.3

10.7 ± 7.2

10.3 ± 5.5

11.7 ± 7.1

12.8 ± 7.5

12.5 ± 7.6

10.8 ± 7.3

17.3 ± 7.3

18.8 ± 9.1

Median year of publication

2000

2004

2006

2004

1999

2004

1999

2004

2003

Median survival (months)

P value

0.002

0.01

0.04

0.02

0.03

0.05

< 0.001

0.02

< 0.001