World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website https://www.wjon.org

Original Article

Volume 11, Number 5, October 2020, pages 188-196

Clinicopathologic Features and Survival Trends for Acinic Cell Carcinoma of the Major Salivary Glands: A Surveillance, Epidemiology, and End Results Population Analysis

**Table 1.** Overall Survival Analysis of Acinar Cell Neoplasms of the Major Salivary Glands
	N	Median survival	Univariate	Multivariate
“Cannot estimate” means statistically a numeric variable is not able to be calculated. ^aIndicates reference group. CI: confidence interval.
Age bands
00 - 09	5	Cannot estimate	Cannot estimate		Cannot estimate
10 - 19	85	Cannot estimate	0.11	0.01 - 0.44	< 0.0001	0.11	0.04 - 0.3	< 0.001
20 - 29	138	Cannot estimate	0.22	0.08 - 0.52	< 0.0001	0.21	0.14 - 0.33	< 0.001
30 - 39	172	Cannot estimate	0.6	0.34 - 1.04	0.0729	0.61	0.56 - 0.67	< 0.001
40 - 49^a	228	417 ± 28.25	Reference			Reference
50 - 59	218	403 ± 101.24	1.72	1.13 - 2.63	0.0085	1.72	1.64 - 1.8	< 0.001
60 - 69	203	219 ± 20.67	4.36	2.90 - 6.69	< 0.0001	4.54	4.16 - 4.97	< 0.001
70 - 79	136	128 ± 17.12	8.67	5.64 - 13.63	< 0.0001	9.42	8.54 - 10.41	< 0.001
80 +	69	403 ± 101.24	18.04	10.52 - 31.84	< 0.0001	21.05	13.11 - 33.85	< 0.001
Stage
Localized^a	947	391 ± 35.25	Reference		Reference
Regional	196	258 ± 67.97	2.11	1.64 - 2.69	< 0.0001	1.22	1.19 - 1.25	< 0.001
Distant	39	83 ± 41.85	7.79	4.70 - 12.38	< 0.0001	3.55	3.06 - 4.12	< 0.001
Unknown	72	270 ± 37.2	1.64	0.94 - 2.68	0.0583	0.87	0.48 - 1.58	0.64
Primary tumor size (mm)
0 - 10^a	92	Cannot estimate	Reference			Reference
11 - 20	370	Cannot estimate	1.57	0.80 - 3.45	0.2378	1.35	1.06 - 1.71	0.02
21 - 30	270	330 ± 88.55	2.85	1.46 - 6.21	0.0007	1.57	1.21 - 2.02	< 0.001
31 - 40	109	Cannot estimate	2.81	1.31 - 6.55	0.0041	1.02	0.85 - 1.22	0.83
41 - 50	42	180 ± 114.72	5.79	2.42 - 14.54	< 0.0001	7.4	6.71 - 8.18	< 0.001
> 50	46	Cannot estimate	6.74	2.85 - 16.85	< 0.0001	2.78	1.24 - 6.25	0.01
Unknown/unspecific	325	330 ± 49.63	2.59	1.36 - 5.54	0.0018	1.54	1.2 - 1.98	< 0.001
Grade
I^a	197	393 ± 77.06	Reference			Reference
II	164	Cannot estimate	1.04	0.64 - 1.67	0.9076	1.01	0.96 - 1.05	0.76
III/IV	55	48 ± 22.99	5.28	3.23 - 8.58	< 0.0001	2.5	2.32 - 2.7	< 0.001
Unknown	838	375 ± 36.82	1.14	0.82 - 1.61	0.4775	1.21	0.86 - 1.69	0.27
Race
American Indian/Alaska Native	5	Cannot estimate	1.73	0.21 - 6.33	0.3238	9.47	2.20 - 40.73	0.003
Asian or Pacific Islander	97	Cannot estimate	0.57	0.32 - 0.94	0.0266	0.78	0.46 - 1.30	0.336
Black	96	379 ± 80.34	0.78	0.48 - 1.21	0.319	1.48	0.93 - 2.34	0.098
Unknown	14	Cannot estimate	0.22	0.01 - 1.25	0.1425	1.07	0.14 - 8.05	0.949
White^a	1,042	335 ± 39.77	Reference			Reference
Sex
Female^a	750	372 ± 35.5	Reference			Reference
Male	504	351 ± 79.47	1.23	0.99 - 1.52	0.0544	1.54	1.24 - 1.90	< 0.001
Radiation
No/unknown	810	391 ± 23.66	0.54	0.44 - 0.67	< 0.0001	0.36	0.16 - 0.83	0.016
Yes^a	444	258 ± 37.77	Reference			Reference
Sequence
Not applicable^a	819	389 ± 31.43	Reference			Reference
Radiation after surgery	422	265 ± 36.43	1.74	1.39 - 2.17	< 0.0001	0.52	0.23 - 1.20	0.125
Radiation before surgery	13	Cannot estimate	1.66	0.66 - 3.48	0.2111	0.67	0.22 - 2.04	0.475
Surgery
No	30	Cannot estimate	2.35	1.16 - 4.28	0.0095	1.66	0.79 - 3.49	0.18
Unknown	5	144 ± 227.59	2.35	0.75 - 5.58	0.0676	2.83	1.76 - 4.54	< 0.001
Yes^a	1,219	372 ± 36.77	Reference			Reference
Diagnosis year
1975 - 1995	461	330 ± 41.09	1.36	1.06 - 1.74	0.0129	1.38	1.04 - 1.83	0.028
1996 - 2016^a	793	Cannot estimate	Reference			Reference
Surgery type
Excision^a	1,204	372 ± 36.48	Reference			Variable not used in multivariate analysis
Limited surgical procedure/biopsy	15	58 ± 17.67	3.51	1.17 - 10.54	0.0005
None	30	Cannot estimate	2.43	1.20 - 4.43	0.0076
Unknown	5	144 ± 227.59	2.38	0.76 - 5.67	0.0643
Diagnosis year
1975 - 1984	157	351 ± 64	1.25	0.74 - 2.09	0.3781	Variable not used in multivariate analysis
1985 - 1994	264	319 ± 42.61	1.89	1.24 - 2.90	0.0021
1995 - 2004	356	Cannot estimate	1.32	0.87 - 2.02	0.1972
2005 - 2016^a	477	Cannot estimate	Reference

Table 1. Overall Survival Analysis of Acinar Cell Neoplasms of the Major Salivary Glands

Median survival

Univariate

Multivariate

Hazard ratio

95% CI

Estimate

95% CI

P value

Estimate

95% CI

P value

“Cannot estimate” means statistically a numeric variable is not able to be calculated. ^aIndicates reference group. CI: confidence interval.

Age bands

00 - 09

Cannot estimate

10 - 19

Cannot estimate

0.11

0.01 - 0.44

< 0.0001

0.11

0.04 - 0.3

< 0.001

20 - 29

138

Cannot estimate

0.22

0.08 - 0.52

< 0.0001

0.21

0.14 - 0.33

< 0.001

30 - 39

172

Cannot estimate

0.6

0.34 - 1.04

0.0729

0.61

0.56 - 0.67

< 0.001

40 - 49^a

228

417 ± 28.25

Reference

50 - 59

218

403 ± 101.24

1.72

1.13 - 2.63

0.0085

1.72

1.64 - 1.8

< 0.001

60 - 69

203

219 ± 20.67

4.36

2.90 - 6.69

< 0.0001

4.54

4.16 - 4.97

< 0.001

70 - 79

136

128 ± 17.12

8.67

5.64 - 13.63

< 0.0001

9.42

8.54 - 10.41

< 0.001

80 +

403 ± 101.24

18.04

10.52 - 31.84

< 0.0001

21.05

13.11 - 33.85

< 0.001

Stage

Localized^a

947

391 ± 35.25

Reference

Regional

196

258 ± 67.97

2.11

1.64 - 2.69

< 0.0001

1.22

1.19 - 1.25

< 0.001

Distant

83 ± 41.85

7.79

4.70 - 12.38

< 0.0001

3.55

3.06 - 4.12

< 0.001

Unknown

270 ± 37.2

1.64

0.94 - 2.68

0.0583

0.87

0.48 - 1.58

0.64

Primary tumor size (mm)

0 - 10^a

Cannot estimate

Reference

11 - 20

370

Cannot estimate

1.57

0.80 - 3.45

0.2378

1.35

1.06 - 1.71

0.02

21 - 30

270

330 ± 88.55

2.85

1.46 - 6.21

0.0007

1.57

1.21 - 2.02

< 0.001

31 - 40

109

Cannot estimate

2.81

1.31 - 6.55

0.0041

1.02

0.85 - 1.22

0.83

41 - 50

180 ± 114.72

5.79

2.42 - 14.54

< 0.0001

7.4

6.71 - 8.18

< 0.001

> 50

Cannot estimate

6.74

2.85 - 16.85

< 0.0001

2.78

1.24 - 6.25

0.01

Unknown/unspecific

325

330 ± 49.63

2.59

1.36 - 5.54

0.0018

1.54

1.2 - 1.98

< 0.001

Grade

I^a

197

393 ± 77.06

Reference

164

Cannot estimate

1.04

0.64 - 1.67

0.9076

1.01

0.96 - 1.05

0.76

III/IV

48 ± 22.99

5.28

3.23 - 8.58

< 0.0001

2.5

2.32 - 2.7

< 0.001

Unknown

838

375 ± 36.82

1.14

0.82 - 1.61

0.4775

1.21

0.86 - 1.69

0.27

Race

American Indian/Alaska Native

Cannot estimate

1.73

0.21 - 6.33

0.3238

9.47

2.20 - 40.73

0.003

Asian or Pacific Islander

Cannot estimate

0.57

0.32 - 0.94

0.0266

0.78

0.46 - 1.30

0.336

Black

379 ± 80.34

0.78

0.48 - 1.21

0.319

1.48

0.93 - 2.34

0.098

Unknown

Cannot estimate

0.22

0.01 - 1.25

0.1425

1.07

0.14 - 8.05

0.949

White^a

1,042

335 ± 39.77

Reference

Sex

Female^a

750

372 ± 35.5

Reference

Male

504

351 ± 79.47

1.23

0.99 - 1.52

0.0544

1.54

1.24 - 1.90

< 0.001

Radiation

No/unknown

810

391 ± 23.66

0.54

0.44 - 0.67

< 0.0001

0.36

0.16 - 0.83

0.016

Yes^a

444

258 ± 37.77

Reference

Sequence

Not applicable^a

819

389 ± 31.43

Reference

Radiation after surgery

422

265 ± 36.43

1.74

1.39 - 2.17

< 0.0001

0.52

0.23 - 1.20

0.125

Radiation before surgery

Cannot estimate

1.66

0.66 - 3.48

0.2111

0.67

0.22 - 2.04

0.475

Surgery

Cannot estimate

2.35

1.16 - 4.28

0.0095

1.66

0.79 - 3.49

0.18

Unknown

144 ± 227.59

2.35

0.75 - 5.58

0.0676

2.83

1.76 - 4.54

< 0.001

Yes^a

1,219

372 ± 36.77

Reference

Diagnosis year

1975 - 1995

461

330 ± 41.09

1.36

1.06 - 1.74

0.0129

1.38

1.04 - 1.83

0.028

1996 - 2016^a

793

Cannot estimate

Reference

Surgery type

Excision^a

1,204

372 ± 36.48

Reference

Variable not used in multivariate analysis

Limited surgical procedure/biopsy

58 ± 17.67

3.51

1.17 - 10.54

0.0005

None

Cannot estimate

2.43

1.20 - 4.43

0.0076

Unknown

144 ± 227.59

2.38

0.76 - 5.67

0.0643

Diagnosis year

1975 - 1984

157

351 ± 64

1.25

0.74 - 2.09

0.3781

Variable not used in multivariate analysis

1985 - 1994

264

319 ± 42.61

1.89

1.24 - 2.90

0.0021

1995 - 2004

356

Cannot estimate

1.32

0.87 - 2.02

0.1972

2005 - 2016^a

477

Cannot estimate

Reference

**Table 2.** Cause-Specific Survival Analysis of Acinar Cell Neoplasms of the Major Salivary Glands
	N	Median survival	Univariate	Multivariate
“Cannot estimate” means statistically a numeric variable is not able to be calculated. ^aIndicates reference group. CI: confidence interval.
Age bands
00 - 09	5	Cannot estimate	Cannot estimate		Cannot estimate
10 - 19	85	Cannot estimate	0	0.00 - 0.44	0.0011	Cannot estimate
20 - 29	138	Cannot estimate	0.14	0.02 - 0.58	0.0012	Cannot estimate
30 - 39	172	Cannot estimate	0.4	0.14 - 0.98	0.0356	Cannot estimate
40 - 49^a	228	Cannot estimate	Reference			Reference
50 - 59	218	Cannot estimate	1.16	0.60 - 2.23	0.6457	Cannot estimate
60 - 69	203	Cannot estimate	2.04	1.11 - 3.85	0.0197	Cannot estimate
70 - 79	136	Cannot estimate	2.05	1.01 - 4.18	0.0326	Cannot estimate
80 +	69	Cannot estimate	8.47	4.19-17.50	< 0.0001	Cannot estimate
Stage
Localized^a	947	Cannot estimate	Reference		Reference
Regional	196	Cannot estimate	4.11	2.73 - 6.17	< 0.0001	1.84	1.18 - 2.86	0.007
Distant	39	Cannot estimate	13.84	6.73 - 26.73	< 0.0001	4.48	2.24 - 8.96	< 0.001
Unknown	72	Cannot estimate	2.07	0.65 - 5.11	0.1078	1.17	0.42 - 3.30	0.762
Primary tumor size (mm)
0 - 10^a	92	Cannot estimate	Reference			Reference
11 - 20	370	Cannot estimate	2.05	0.48 - 18.43	0.5565	1.46	0.65 - 3.26	0.36
21 - 30	270	Cannot estimate	4.85	1.20 - 42.39	0.0157	2	0.46 - 8.65	0.35
31 - 40	109	Cannot estimate	2.81	1.31 - 6.55	0.0041	1.25	0.64 - 2.47	0.51
41 - 50	42	Cannot estimate	15.99	3.37 - 151.34	< 0.0001	11.52	5.91 - 22.44	< 0.001
> 50	46	Cannot estimate	14.79	2.86 - 146.58	0.0002	3.84	2.06 - 7.17	< 0.001
Unknown/unspecific	325	Cannot estimate	5.38	1.41 - 45.81	0.0051	2.76	1.12 - 6.83	0.03
Grade
I^a	197	Cannot estimate	Reference			Reference
II	164	Cannot estimate	0.79	0.31 - 1.93	0.6817	0.96	0.41 - 2.28	0.93
III/IV	55	280 ± 339.83	8.36	4.10 - 17.49	< 0.0001	3.2	3.16 - 3.24	< 0.001
Unknown	838	Cannot estimate	1.04	0.59 - 1.94	> 0.9999	1.08	0.94 - 1.25	0.29
Race
American Indian/Alaska Native	5	Cannot estimate	4.59	0.55 - 17.08	0.0732	24.75	4.82 - 127.19	< 0.001
Asian or Pacific Islander	97	Cannot estimate	0.4	0.11 - 1.06	0.0849	0.66	0.24 - 1.82	0.417
Black	96	Cannot estimate	0.6	0.22 - 1.35	0.3097	0.91	0.38 - 2.18	0.826
Unknown	14	Cannot estimate	0.7	0.02 - 3.98	> 0.9999	1.62	0.17 - 15.75	0.676
White^a	1,042	Cannot estimate	Reference			Reference
Sex
Female^a	750	Cannot estimate	Reference			Reference
Male	504	Cannot estimate	1.58	1.09 - 2.29	0.0123	1.68	1.15 - 2.43	0.007
Radiation
No/unknown	810	Cannot estimate	0.29	0.20 - 0.42	< 0.0001	0.78	0.49 - 1.25	0.31
Yes^a	444	Cannot estimate	Reference			Reference
Sequence
Not applicable^a	819	Cannot estimate	Reference			Reference
Radiation after surgery	422	Cannot estimate	1.74	1.39 - 2.17	< 0.0001	0.46	0.15 - 1.37	0.163
Radiation before surgery	13	Cannot estimate	3.1	0.62 - 9.62	0.0797	0.62	0.13 - 3.07	0.558
Surgery
No	30	Cannot estimate	2.74	0.87 - 6.60	0.0413	1.46	0.48 - 4.52	0.507
Unknown	5	Cannot estimate	3.69	0.44 - 13.81	0.1058	2.98	0.56 - 15.96	0.202
Yes^a	1,219	Cannot estimate	Reference			Reference
Diagnosis year
1975 - 1995	461	Cannot estimate	1.32	0.88 - 1.97	0.1712	1.28	0.80 - 2.04	0.305
1996 - 2016^a	793	Cannot estimate	Reference			Reference
Surgery type
Excision^a	1,204	Cannot estimate	Reference			Variable not used in multivariate analysis
Limited surgical procedure/biopsy	15	Cannot estimate	4.8	1.52 - 11.60	0.0048
None	30	Cannot estimate	2.86	0.91 - 6.92	0.0352
Unknown	5	Cannot estimate	3.79	0.45 - 14.17	0.1018
Diagnosis year
1975 - 1984	157	Cannot estimate	1.75	0.85 - 3.59	0.1112	Variable not used in multivariate analysis
1985 - 1994	264	Cannot estimate	1.66	0.87 - 3.22	0.1248
1995 - 2004	356	Cannot estimate	1.44	0.78 - 2.72	0.2512
2005 - 2016^a	477	Cannot estimate	Reference

Table 2. Cause-Specific Survival Analysis of Acinar Cell Neoplasms of the Major Salivary Glands

Median survival

Univariate

Multivariate

Hazard ratio

95% CI

Estimate

95% CI

P value

Estimate

95% CI

P value

“Cannot estimate” means statistically a numeric variable is not able to be calculated. ^aIndicates reference group. CI: confidence interval.

Age bands

00 - 09

Cannot estimate

10 - 19

Cannot estimate

0.00 - 0.44

0.0011

Cannot estimate

20 - 29

138

Cannot estimate

0.14

0.02 - 0.58

0.0012

Cannot estimate

30 - 39

172

Cannot estimate

0.4

0.14 - 0.98

0.0356

Cannot estimate

40 - 49^a

228

Cannot estimate

Reference

50 - 59

218

Cannot estimate

1.16

0.60 - 2.23

0.6457

Cannot estimate

60 - 69

203

Cannot estimate

2.04

1.11 - 3.85

0.0197

Cannot estimate

70 - 79

136

Cannot estimate

2.05

1.01 - 4.18

0.0326

Cannot estimate

80 +

Cannot estimate

8.47

4.19-17.50

< 0.0001

Cannot estimate

Stage

Localized^a

947

Cannot estimate

Reference

Regional

196

Cannot estimate

4.11

2.73 - 6.17

< 0.0001

1.84

1.18 - 2.86

0.007

Distant

Cannot estimate

13.84

6.73 - 26.73

< 0.0001

4.48

2.24 - 8.96

< 0.001

Unknown

Cannot estimate

2.07

0.65 - 5.11

0.1078

1.17

0.42 - 3.30

0.762

Primary tumor size (mm)

0 - 10^a

Cannot estimate

Reference

11 - 20

370

Cannot estimate

2.05

0.48 - 18.43

0.5565

1.46

0.65 - 3.26

0.36

21 - 30

270

Cannot estimate

4.85

1.20 - 42.39

0.0157

0.46 - 8.65

0.35

31 - 40

109

Cannot estimate

2.81

1.31 - 6.55

0.0041

1.25

0.64 - 2.47

0.51

41 - 50

Cannot estimate

15.99

3.37 - 151.34

< 0.0001

11.52

5.91 - 22.44

< 0.001

> 50

Cannot estimate

14.79

2.86 - 146.58

0.0002

3.84

2.06 - 7.17

< 0.001

Unknown/unspecific

325

Cannot estimate

5.38

1.41 - 45.81

0.0051

2.76

1.12 - 6.83

0.03

Grade

I^a

197

Cannot estimate

Reference

164

Cannot estimate

0.79

0.31 - 1.93

0.6817

0.96

0.41 - 2.28

0.93

III/IV

280 ± 339.83

8.36

4.10 - 17.49

< 0.0001

3.2

3.16 - 3.24

< 0.001

Unknown

838

Cannot estimate

1.04

0.59 - 1.94

> 0.9999

1.08

0.94 - 1.25

0.29

Race

American Indian/Alaska Native

Cannot estimate

4.59

0.55 - 17.08

0.0732

24.75

4.82 - 127.19

< 0.001

Asian or Pacific Islander

Cannot estimate

0.4

0.11 - 1.06

0.0849

0.66

0.24 - 1.82

0.417

Black

Cannot estimate

0.6

0.22 - 1.35

0.3097

0.91

0.38 - 2.18

0.826

Unknown

Cannot estimate

0.7

0.02 - 3.98

> 0.9999

1.62

0.17 - 15.75

0.676

White^a

1,042

Cannot estimate

Reference

Sex

Female^a

750

Cannot estimate

Reference

Male

504

Cannot estimate

1.58

1.09 - 2.29

0.0123

1.68

1.15 - 2.43

0.007

Radiation

No/unknown

810

Cannot estimate

0.29

0.20 - 0.42

< 0.0001

0.78

0.49 - 1.25

0.31

Yes^a

444

Cannot estimate

Reference

Sequence

Not applicable^a

819

Cannot estimate

Reference

Radiation after surgery

422

Cannot estimate

1.74

1.39 - 2.17

< 0.0001

0.46

0.15 - 1.37

0.163

Radiation before surgery

Cannot estimate

3.1

0.62 - 9.62

0.0797

0.62

0.13 - 3.07

0.558

Surgery

Cannot estimate

2.74

0.87 - 6.60

0.0413

1.46

0.48 - 4.52

0.507

Unknown

Cannot estimate

3.69

0.44 - 13.81

0.1058

2.98

0.56 - 15.96

0.202

Yes^a

1,219

Cannot estimate

Reference

Diagnosis year

1975 - 1995

461

Cannot estimate

1.32

0.88 - 1.97

0.1712

1.28

0.80 - 2.04

0.305

1996 - 2016^a

793

Cannot estimate

Reference

Surgery type

Excision^a

1,204

Cannot estimate

Reference

Variable not used in multivariate analysis

Limited surgical procedure/biopsy

Cannot estimate

4.8

1.52 - 11.60

0.0048

None

Cannot estimate

2.86

0.91 - 6.92

0.0352

Unknown

Cannot estimate

3.79

0.45 - 14.17

0.1018

Diagnosis year

1975 - 1984

157

Cannot estimate

1.75

0.85 - 3.59

0.1112

Variable not used in multivariate analysis

1985 - 1994

264

Cannot estimate

1.66

0.87 - 3.22

0.1248

1995 - 2004

356

Cannot estimate

1.44

0.78 - 2.72

0.2512

2005 - 2016^a

477

Cannot estimate

Reference