World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website https://www.wjon.org

Original Article

Volume 12, Number 4, August 2021, pages 104-110

Quality of Life in Patients With Severe Skin Reactions in Course of First-Generation Epidermal Growth Factor Receptor Inhibitors Monoclonal Antibodies (Our Experience With Cetuximab)

Tables

Table 1. Socio-Demographic Data (N = 100)
 
ECGO: Eastern Cooperative Oncology Group.
Age (range)58 (35 - 75)
Sex
  Females66 (66%)
  Males34 (34%)
ECOG performance status
  014 (14%)
  137 (37%)
  248 (49%)
First line of chemotherapy
  Yes51 (51%)
  No49 (49%)
Civil status
  Single15 (15%)
  Married76 (76%)
  Widowed5 (5%)
  Separated/divorced4 (4%)
Education level
  Primary school2 (2%)
  Secondary school8 (8%)
  High school53 (53%)
  Graduated37 (37%)

 

Table 2. Skin Toxicity Using CTCAE (N = 100)
 
Grade 0Grade 1Grade 2Grade 3Grade 4
CTCAE: Common Terminology Criteria for Adverse Event.
Skin rash0 (0%)10 (10%)35 (35%)47 (47%)8 (8%)

 

Table 3. Pearson’s Correlation of Skin Rash and QoL in Patients Receiving Cetuximab (N = 100)
 
Skin rashQoL
*P < 0.01. QoL: quality of life.
Skin rash1-0.65*
QoL-0.65*1

 

Table 4. Average Scores and Standard Deviation of Questionnaire EORTC QLQ-C30 (N = 100)
 
QoLAverage (SD)
EORTC QLQ-C30: European Organization for Research and Treatment of Cancer; QoL: quality of life; SD: standard deviation.
Functional scale
  Physical function77.6 (16.5)
  Functional role65.8 (29.4)
  Emotional state81.6 (23.1)
  Cognitive function88.4 (26.3)
  Social function45.3 (21.7)
  Global health/QoL55.9 (18.5)
  Insomnia46.9 (18.7)
Symptom scale
  Fatigue59.4 (26.2)
  Pain13.2 (25.1)
  Dyspnea11.5 (21.7)
  Constipation19.4 (26.1)
  Appetite loss28.7 (29.2)
  Diarrhea22.8 (29.7)
  Nausea, vomiting41.3 (22.6)
  Financial difficulties14.7 (19.3)

 

Table 5. Average Score and Standard Deviation of BUT Test (N = 100)
 
Average (SD)
BUT: body uneasiness test; SD: standard deviation.
Weight phobia9.7 (7.4)
Concern for the image of the body18.2 (8.5)
Avoidance behavior16.3 (7.8)
Compulsive control of image6.6 (16.4)
Depersonalization9.2 (11.17)