| World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc |
| Journal website https://www.wjon.org |
Original Article
Volume 13, Number 4, August 2022, pages 185-189
Expression of Programmed Death Ligand 1 in Breast Cancer in Mexican Women
Table
| PD-L1 expression in breast cancer tumors | Total number | Positive cases | % Positive cases | Negative cases |
|---|---|---|---|---|
| Luminal A breast cancer is hormone-receptor positive (estrogen-receptor and/or progesterone-receptor positive at least ≥ 1% of tumor cells), HER2-negative (≤ 10% tumor cells membrane) and has low levels of the protein Ki-67 in tumor cells (≤ 14%). Luminal B breast cancer is hormone-receptor positive (estrogen-receptor and/or progesterone-receptor positive at least ≥ 1% in tumor cells), and either HER2-positive (at least >10% of tumor cells complete membrane) or HER2-negative with high levels of Ki-67 (> 14%). Triple-negative/basal-like breast cancer is hormone-receptor negative (estrogen-receptor and progesterone-receptor negative; < 1% of tumor cells) and HER2-negative (≤ 10% tumor cells membrane). PD-L1: programmed death ligand 1; TNM: tumor, node, metastases. | ||||
| Tumoral size (TS) | ||||
| T1 (< 20 mm) | 26 | 5 | 19% | 21 |
| T2 (> 20 mm - < 50 mm) | 30 | 11 | 37% | 19 |
| T3 (> 50 mm) | 6 | 3 | 50% | 3 |
| T4 (thoracic wall invasion or tumoral ulceration) | 1 | 1 | 100% | 0 |
| Total | 63 | 20 | 43 | |
| Node metastases (PN) | ||||
| N0 (no metastases) | 36 | 9 | 25% | 27 |
| N1 (micrometastases or metastases in 1 - 3 lymph nodes) | 13 | 5 | 38% | 8 |
| N2 (metastases in 4 - 9 axillary lymph nodes | 4 | 3 | 75% | 1 |
| N3 (metastases in 10 or more lymph nodes) | 10 | 3 | 30% | 7 |
| Total | 63 | 20 | 43 | |
| Immunochemistry | ||||
| Luminal A | 20 | 3 | 15% | 17 |
| Luminal B HER2 positive | 4 | 0 | 0 | 4 |
| Luminal B HER2 negative | 22 | 8 | 36% | 14 |
| HER2 | 5 | 2 | 40% | 3 |
| Triple negative | 12 | 7 | 58% | 5 |
| Total | 63 | 20 | 43 | |
| Histological grade | ||||
| Grade 1 | 6 | 0 | 0 | 6 |
| Grade 2 | 31 | 7 | 23% | 24 |
| Grade 3 | 26 | 13 | 50% | 13 |
| Total | 63 | 20 | 43 | |