World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website https://www.wjon.org

Case Report

Volume 14, Number 4, August 2023, pages 309-315

A Case of BRCA2-Pathogenic Variant Breast Cancer With Metachronous Endometrial Cancer and Pancreatic Cancer

Figures

Figure 1.
Figure 1. Histopathological results. Pathological analysis of surgical tissue from (a) breast, (b) uterus, and (c) abdominal tumor.
Figure 2.
Figure 2. (a, b) Abdominal CT images revealing the multiple abdominal mass (arrows). CT: computed tomography.
Figure 3.
Figure 3. Examination results for mass in her thoracic cavity by (a) CT, (b) PET-CT (SUVmax = 2.5), and (c) pathological analysis. ER: estrogen receptor; PgR: progesterone receptor; H&E: hematoxylin and eosin stain; CT: computed tomography; PET-CT: positron emission tomography-computed tomography; SUVmax: maximum standardized uptake value.
Figure 4.
Figure 4. (a, b) PET-CT images showed tumors in pancreas and liver (SUVmax = 4.0 and 4.6, respectively) (arrows). PET-CT: positron emission tomography-computed tomography; SUVmax: maximum standardized uptake value.
Figure 5.
Figure 5. Pathological analysis of pancreatic tumor tissue. H&E: hematoxylin and eosin stain. ER: estrogen receptor; PgR: progesterone receptor; H&E: hematoxylin and eosin stain; GATA-3: GATA binding protein 3; PAX8: paired box 8; GCDFP15: gross cystic disease fluid protein 15.
Figure 6.
Figure 6. Transition graph of tumor markers (CA19-9, SPAN-1, and DUPAN-2). GEM+nabPTX: gemcitabine with nab-paclitaxel; DUPAN-2: Duke pancreatic monoclonal antigen type 2; SPAN-1: s-pancreas antigen-1; CA19-9: carbohydrate antigen 19-9.
Figure 7.
Figure 7. Distribution of MPMNs with breast cancer patients. (a) Synchronous vs. metachronous. (b) Breast cancer onset timing. (c) Comorbid cancer. MPMNs: multiple primary malignant neoplasms; GIST: gastrointestinal stromal tumor.