Figures
Figure 1. Diagram depicting the grouping of patients according to various matching criteria. Patients were initially matched by age, sex, and CCI. Patients were then subsequently matched by treatment. Incidence of CRC was assessed in all groups. CRC: colorectal carcinoma; CCI: Charlson Comorbidity Index; C. diff: Clostridioides difficile.
Figure 2. Incidence of colorectal cancer in patients with (dark blue column on left) and without (light blue column on left) a history of CDI after initial matching. Incidence of colorectal cancer in patients with (dark blue column on right) and without (light blue column on right) a history of CDI after subsequent matching by treatment. Significance was assessed using Student’s t-test. CRC: colorectal carcinoma; CCI: Charlson Comorbidity Index; CDI: Clostridioides difficile infection; C. diff: Clostridioides difficile.
Figure 3. Incidence of colorectal cancer by age of patient, separated by prior history of CDI (dark blue columns) and no prior history of CDI (light blue columns). CDI: Clostridioides difficile infection.
Figure 4. Incidence of colorectal cancer by region of residence in the United States, separated by prior history of CDI (dark blue columns) and no prior history of CDI (light blue columns). MW: Midwest; NE: Northeast; SO: South; WE: West; CDI: Clostridioides difficile infection.
Figure 5. Calculation of relative risk (RR). RR = 0.59 in patients with CDI prior to matching for treatment (bottom data point) and RR = 0.50 patients with CDI following treatment matching (top data point). CDI: Clostridioides difficile infection.
Figure 6. Incidence of colorectal cancer in obese patients with CDI (dark blue column on left) and obese patients without CDI (light blue column on left) using the original matching criteria. Incidence of colorectal cancer in obese patients with CDI (dark blue column on right) and obese patients without CDI (light blue column on right) after obesity-controlled matching. Significance was assessed using Student’s t-test. *P < 0.05. CDI: Clostridioides difficile infection.