World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website https://www.wjon.org

Review

Volume 15, Number 3, June 2024, pages 394-404

Diagnosis and Management of Desmoid Fibromatosis of the Breast

Figures

Figure 1.
Figure 1. Fibromatosis infiltrating around normal breast epithelium (black arrow).
Figure 2.
Figure 2. The spindle cells of fibromatosis show aberrant β-catenin nuclear immunoreactivity (black arrow).
Figure 3.
Figure 3. Low power show moderate cellularity with alternating hypocellular (black arrow) and hypercellular area (red arrow) and lacking circumscription.
Figure 4.
Figure 4. (a) Long sweeping fascicles (black arrows) and intersecting fascicles (red arrows) are characteristic of desmoid tumor of breast. (b) Bland spindle cell proliferation (black arrows), nuclei are elongated with rounded ends and lack nuclear pleomorphism and demonstrate no mitoses
Figure 5.
Figure 5. Proposed management algorithm for breast fibromatosis.

Table

Table 1. Case Series of Desmoid Fibromatosis in the Recent Literature
 
StudyYearNumber of patientsPrimary mode of diagnosisAssociationsNotes
APC: adenomatosis polyposis coli; CNB: core needle biopsy; FNA: fine needle aspiration; WLE: wide local excision.
Benej et al [4]20172CNBSporadicBoth managed with WLE
Al Ali et al [5]20191Not specifiedPost-breast reconstructive surgeryIntrathoracic involvement with cardiac compression
Hammood et al [6]20211Excisional biopsySporadicTreated with WLE
Reis-Filho et al [7]20011Excisional biopsySporadicAbdominal and breast tumors
Taylor et al [8]20111CNBSporadicCNB showed phyllodes; patient underwent WLE
Wongmaneerung [10] et al20162Excisional biopsySporadicBoth underwent WLE
Privette et al [11]20051Excisional biopsyPrior history of breast biopsiesMastectomy
Povoski et al [12]20061CNBPrior history of breast biopsiesUnderwent WLE
Greenberg et al [13]20021FNASporadicFNA benign, underwent WLE
Hennuy et al [14]20221CNBSporadicUnderwent active surveillance, continuous regression at 3 years
Lorenzen et al [15]202115CNBPrior history of breast biopsies (33%)All underwent WLE
Boland et al [16]202016CNBOne patient with APC gene mutation, all others sporadic13/16 had WLE, three had “watch-and-wait”
Neuman et al [17]200832Nine underwent FNA, CNB in sevenPrior surgery in 44%78% underwent surgery