World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access |
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc |
Journal website https://www.wjon.org |
Original Article
Volume 000, Number 000, July 2024, pages 000-000
Patterns and Frequency of Pathogenic Germline Variants Among Prostate Cancer Patients Utilizing Multi-Gene Panel Genetic Testing
Figure
Table
Characteristics | N (%) | PGVs, N (%) | P-value |
---|---|---|---|
MGPT: multi-gene panel testing; PGVs: pathogenic germline variants. | |||
Age at diagnosis (years) | 0.542 | ||
Median (range) | 67 (45 - 86) | ||
≤ 65 | 106 (48.9) | 9 (8.5) | |
≥ 65 | 125 (54.1) | 8 (6.4) | |
Genetic testing | 0.884 | ||
Prostate MGPT | 113 (48.9) | 8 (7.1) | |
Multi-cancer MGPT | 118 (51.1) | 9 (7.6) | |
Gleason score | 0.935 | ||
< 8 | 77 (33.3) | 6 (7.8) | |
≥ 8 | 146 (63.2) | 11 (7.5) | |
Stage at diagnosis | 0.582 | ||
Localized | 124 (53.7) | 8 (6.5) | |
Metastatic | 107 (46.3) | 9 (8.4) | |
Castration status | 0.794 | ||
Sensitive | 65 (28.1) | 5 (7.7) | |
Resistant | 44 (19.0) | 4 (9.1) | |
Family history | 0.414 | ||
Positive | 171 (74.0) | 14 (8.2) | |
Negative | 60 (26.0) | 3 (5.0) |