| World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc |
| Journal website http://www.wjon.org |
Original Article
Volume 1, Number 6, December 2010, pages 236-241
A Case-Control Study of TP53 R72P Polymorphism in the Breast Cancer Patients of Ethnic Kashmiri Population
Tables
| Variables | Cases (n = 130) | ||||
|---|---|---|---|---|---|
| Total N = 130 | RR 29 (22.3%) | R/P 37 (28.4%) | PP 64 (49.2%) | P Value; χ2 | |
| Dwelling | |||||
| Rural: | 45 (34.6%) | 08 (17.77%) | 12 (26.66%) | 25 (55.55%) | 0.52 ; 1.27 |
| Urban: | 85 (65.4%) | 21 (24.70%) | 25 (29.41%) | 29 (34.11%) | |
| Smoking Status | |||||
| Never: | 93 (71.5%) | 18 (19.35%) | 27 (29.03%) | 48 (51.61%) | 0.42 ; 1.69 |
| Ever: | 37 (28.5%) | 11 (29.72%) | 10 (27.02%) | 16 (43.24%) | |
| Menopausal Status | |||||
| Pre: | 36 (27.7%) | 12 (33.33%) | 12 (33.33%) | 12 (33.33%) | 0.04 ; 6.16 |
| Post: | 94 (72.3%) | 17 (18.08%) | 25 (26.59%) | 54 (57.44%) | |
| Nodal Status | |||||
| Involved | 34 (26.2%) | 12 (35.29%) | 09 (26.47%) | 13 (38.23%) | 0.09 ; 4.68 |
| Not Involved | 96 (73.8%) | 17 (17.70%) | 28 (29.16%) | 51 (53.12%) | |
| Tumor Stage | |||||
| II(a+b) | 72 (55.4%) | 19 (26.38%) | 25 (34.72%) | 28 (38.88%) | 0.03 ; 6.93 |
| III(a+b)+ IV | 58 (44.6%) | 10 (17.24%) | 12 (20.68%) | 36 (62.66%) | |
| Histopathological Tumor | |||||
| Grade | |||||
| PD | 25 (19.23%) | 08 (32.0%) | 08 (32.0%) | 09 (36.0%) | 0.04 ; 6.21 |
| MD + WD | 58 + 47 (80.76%) | 21 (20.0%) | 29 (27.61%) | 55 (52.38%) | |
| TP53 R72P Genotype | Cases (n = 130) | Controls (n = 220) | OR (95% CI ); p value |
|---|---|---|---|
| RR | 29 (22.31%) | 46 (20.91%) | 1 (Ref) |
| RP | 37 (28.46%) | 107 (48.64%) | 0.548 (0.30-0.99); 0.06 |
| PP | 64 (49.23%) | 25 (11.36%) | 4.06 (2.10-7.82); 0.00002 |
| RP+PP | 101 (77.69%) | 132 (60.0%) | 1.21 (0.71-2.06); 0.50 |