| World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc |
| Journal website http://www.wjon.org |
Review
Volume 2, Number 5, October 2011, pages 209-216
Primary Hepatic Neuroendocrine Tumor: What Do We Know Now?
Table
| Characteristics | N* (%) |
|---|---|
| *This is based on detail of the individual cases reviewed. | |
| Age(years) | |
| Range | 8-89 |
| Mean | 51.9 ± 16.5 |
| Gender | |
| Male | 61/124 (49.2%) |
| Female | 63/124 (50.8%) |
| Presentation | |
| Symptomatic | 88/120 (73.3%) |
| Abdominal Pain | 57/88 (65.0%) |
| Abdominal Mass | 11/88 (12.5%) |
| Jaundice | 4/88 (45.0%) |
| Classic carcinoid syndrome | 6/88 (6.8%) |
| Asymptomatic | 32/120 (26.7%) |
| Method of diagnosis | |
| Surgery | 94/124 (77.4%) |
| Biopsy | 14/124 (11.3%) |
| Autopsy | 14/124 (11.3%) |
| Tumor location | |
| Right lobe | 60/124 (48.4%) |
| Left lobe | 41/124 (33.1%) |
| Bi-lobar | 23/124 (18.5%) |
| Tumor Size | |
| Range (cm) | 1.5-27 |
| Mean (cm) | 9.4 (SD ± 5.8) |
| Tumor number | |
| Single | 90/118 (76.3%) |
| Multiple | 28/118 (23.7%) |
| Management | |
| Liver resection | 98/116 (84.5%) |
| Liver transplant | 3/116 (2.6%) |
| Chemotherapy | 7/116 (6.0%) |
| Transcatherer arterial embolization(TACE) | 5/116 (4.3%) |
| Radiofrequency ablation | 1/116 (0.8%) |
| Immunohistochemical stains | |
| Chromogranin A | 90/95 (94.7%) |
| Synaptophysin | 48/95 (50.5%) |
| Cytokeratin | 13/95 (13.7%) |
| Neuron specific enolase | 46/95 (48.4%) |
| Disease free interval (months) | |
| Minimum | 1 |
| Maximum | 180 |
| Mean | 33.6 |
| Recurrence | |
| Recurrence | 23/116 (19.8%) |
| No recurrence | 93/116 (80.2%) |
| Survival | |
| Death | 34/118 (28.8%) |
| Alive | 84/118 (71.2%) |
| Follow up (months) | |
| Longest survival | > 192 |
| Shortest survival | < 1 |
| Mean survival | 41 |
| Metastases | |
| Metastase | 21/113 (18.6%) |
| No metastases | 92/113 (81.4%) |
| Survival | |
| 1 year | 82.0% (CI 0.74-0.89) |
| 5 years | 75.0% (CI 0.66-0.83) |
| 10 years | 73.4% (CI 0.64-0.82) |