World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website

Case Report

Volume 7, Number 4, August 2016, pages 85-90

Resilience Through Squamous Cell Carcinoma and Rhabdomyosarcoma of Oral Cavity: A Unique Case Report


Figure 1.
Figure 1. Squamous cell carcinoma of tongue (SCCOT): H&E at 400 magnification showing (A) nest and cords of atypical squamous cells exhibiting pleomorphic vesicular nuclei with prominent nucleoli having abundant cytoplasm and keratin pearls and (B) individual cell keratinization.
Figure 2.
Figure 2. (A) A 3 × 2 cm growth at left mandibular quadrant with loss of canine, first and second premolars. (B) Site of previous hemi-glossectomy.
Figure 3.
Figure 3. (A) H&E at 100 magnifications shows sheets of neoplastic spindle cells. (B) H&E at 400 magnification shows clusters of atypical cells with hyperchromatic nuclei, abundant eosinophilic cytoplasm and increased nucleus to cytoplasmic ratio.
Figure 4.
Figure 4. Immunohistochemistry (1). Tumor cells stain positive for (A) desmin, (B) myogenin, (C) ASMA, and (D) vimentin.
Figure 5.
Figure 5. Immunohistochemistry (2). Tumor cells stain negative for (A) CK AE1/CK AE3 and (B) S-100.
Figure 6.
Figure 6. Exposed reconstruction plate.


Table 1. Immunocytological Findings of the Resected Specimen
Immunological markersFindings
Cytokeratin AE1/AE3Negative
Cytokeratin 8/18Negative


Table 2. Stages of Rhabdomyosarcoma According to International Rhabdomyosarcoma Study Group (IRSG) [3]
StageLocationNodal statusMetastasis
Stage IOrbit, head and neck, non-parameningeal, and genitourinary
Any size
N0 or N1No metastasis
Stage IIAny other site < 5 cmN0No metastasis
Stage IIIAny other site < 5 cm
Any other site > 5 cm
N0 or N1
No metastasis
Stage IVTumor at any location and of any sizeN0 or N1M1