World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
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Case Report

Volume 7, Number 5-6, December 2016, pages 119-123

Radiation-Induced Malignancies: Our Experiences With Five Cases

Figures

Figure 1.
Figure 1. (a) Moderately differentiated squamous cell carcinoma. (b) PET-CECT showing FDG avid mass lesion in esophagus at level of D2-D4.
Figure 2.
Figure 2. (a) MRI of abdomen shows uterine parenchyma is completely replaced by a large heterogenous mass lesion having solid and cystic areas, measuring 11 × 13.1 × 14.7 cm. (b) On gross examination of uterus specimen, a large tumor measuring 17 × 14 × 7 cm was identified. (c) Histopathological examination is showing a cellular tumour consisting of oval to elongated and polygonal cells. The elongated cells are arranged in palisading and haphazard pattern. The polygonal cells at places are forming ill-defined trabecular and glandular patterns (× 40). (d) Immunohistochemistry (IHC) showing positivity for vimentin, myosin, CK and focally for EMA (× 40).
Figure 3.
Figure 3. (a) CECT neck showing mass of size 3 × 2 × 1 cm on right side base of tongue with floor of mouth involvement. (b) The tumour cells are arranged in small nests. The cells have round to oval hyperchromatic nuclei with scant cytoplasm. (c) IHC showing positivity for neuron specific enolase.
Figure 4.
Figure 4. (a) CECT of neck showing enhancing mass measuring in right side supraglottic larynx. (b) Poorly differentiated squamous cell carcinoma. (c) CECT showing enhancing mass in left lower GBS and extending up to skin.

Table

Table 1. Our Five Cases of Radiation-Induced Malignancies
 
CasePrimary diagnosisHistology of primaryRadiotherapy doseChemotherapy agentLatent period (years)Site of RIMHistology of RIMTreatment of RIM
IDC: infiltrating ductal carcinoma; CAF: cyclophosphamide, adriamycin, 5-florouracil; E: esophagus; MDSCC: moderately differentiated squamous cell carcinoma; RT: radiotherapy; U: uterus; CS: carcinosarcoma; CT: chemotherapy; BOT: base of tongue; NEC: neuroendocrine carcinoma; BM: buccal mucosa; L: leiomyosarcoma; PDSCC: poorly differentiated squamous cell carcinoma; GBS: gingivobuccal sulcus; CCRT: concurrent chemoradiotherapy.
1Carcinoma breastIDC50 Gy in 25 fractionsSix cycles of CAF regimen14EMDSCCPalliative RT
2Carcinoma cervixMDSCC50 Gy in 25 fractions f/b 7 Gy in 3 fractionsCisplatin13UCSCT
3Carcinoma BOTMDSCC66 Gy in 33 fractionsCisplatin7BOTNECCT
4Carcinoma BMWDSCC66 Gy in 33 fractionsCisplatin4BMLSurgery
5Carcinoma supraglottisPDSCC66 Gy in 33 fractionsCisplatin3GBSMDSCCCCRT