World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website http://www.wjon.org

Case Report

Volume 8, Number 2, April 2017, pages 53-57

Gliosarcoma in Young Adults: A Rare Variant of Glioblastoma

Figures

Figure 1.
Figure 1. MRI of brain showing hyperintensity in the parieto-occipital lobe of brain (a). MRI of brain showing postoperative defect after complete excision of tumor (b).
Figure 2.
Figure 2. Tumor cells arranged in diffused sheets with areas of necrosis and vascular endothelial proliferation (× 40). Cells show marked nuclear atypia, pleomorphism and hyperchromasia along with atypical mitosis and focal areas of elongated and spindle shaped tumor cells.

Table

Table 1. Patient Characteristics and Treatment Details
 
Patients1234
Age35 years35 years16 years23 years
SexMaleFemaleMaleFemale
Site of tumorFrontal lobeParieto-occipital lobeFronto-temporo-parietal regionFrontal lobe
SurgeryComplete macroscopic tumor removalGross total excisionFronto-temporo-parietal craniotomy with cyst decompression and excisionGross total excision
Radiotherapy60 Gy/30 fractions
Over 6 weeks with concurrent temozolmide		60 Gy/30 fractions
Over 6 weeks with concurrent temozolmide		60 Gy/30 fractions
Over 6 weeks with concurrent temozolmide		60 Gy/30 fractions
Over 6 weeks with concurrent temozolmide
ChemotherapySix cycles with temozolomideSix cycles with temozolomideSix cycles with temozolomideSix cycles with temozolomide
Follow-up (months)Recurrence after 1.5 years, re-excision followed by six cycles chemotherapy with temozolomide. Now on follow-up for 9 months6 months4 months11 months