Role of Taxanes in Triple-Negative Breast Cancer: A Study From Tertiary Cancer Center in South India

K.C. Lakshmaiah, Abhishek Anand, K. Govind Babu, Lokanatha Dasappa, Linu Abraham Jacob, Suresh Babu M.C., K.N. Lokesh, A.H. Rudresha, L.K. Rajeev, Smitha C. Saldanha, G.V. Giri, Deepak Koppaka

Abstract


Background: Breast cancer is the most common female cancer seen globally. Triple-negative breast cancer (TNBC) is a special subtype without any obvious target and optimum treatment remains challenging. The aim was to study the clinical, pathological profile and treatment outcome of TNBC patients.

Methods: This was a retrospective observational study of TNBC patients diagnosed from January 2010 to June 2012 at a tertiary cancer center in South India. Patient's clinical and pathological characteristics were studied. The 5-year estimate of survival for non-metastatic TNBC was done using the Kaplan-Meier method.

Results: Out of 804 patients of breast cancer, 237 were diagnosed as TNBC. The median age was 45 years and 58% were premenopausal. The 5-year disease-free survival (DFS) and overall survival (OS) for non-metastatic TNBC patients were 59% and 74%, respectively. The addition of a taxane to anthracycline-based regimen did not show a significant difference in DFS (P = 0.885) as well as OS (P = 0.856).

Conclusion: The role of adding taxanes to anthracycline-based chemotherapy in adjuvant setting for TNBC remains controversial and larger prospective studies are warranted.




World J Oncol. 2017;8(4):110-116
doi: https://doi.org/10.14740/wjon1054w


Keywords


Triple-negative breast cancer; Taxane

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