An Extremely Rare Case of Splenic Rupture Secondary to Metastatic Gestational Choriocarcinoma

Doan Tien Luu, Nguyen Minh Duc, Thieu-Thi Tra My, Tran-Van Giang, Luong Viet Bang, Bui-Van Lenh


Gestational choriocarcinoma (GC) is an uncommon malignant tumor consisting of trophoblastic cells. The lungs, liver, and central nervous system are the most common metastatic sites for this disease. However, splenic metastasis is unusual and might result in spontaneous rupture. Symptoms associated with splenic rupture may be the first presentation of malignancy. A thorough medical history and examination are necessary to detect the primary lesion. Herein, we present a case of a 23-year-old female who had splenic rupture secondary to choriocarcinoma metastasis. Although the emergency condition had been solved, the patient died 1 month after due to brain metastasis. The goal of this article was to report a new case of spontaneous splenic rupture caused by choriocarcinoma metastasis and to review the existing literature on splenic metastases associated with GC, including the epidemiology and etiology.

World J Oncol. 2021;12(1):39-43


Choriocarcinoma; Gestational trophoblastic neoplasm; Splenic metastasis; Splenic rupture

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