A Case of Refractory Esophageal Ulcer Caused by Radiotherapy for Hepatocellular Carcinoma

Kazu Hamada, Tohru Itoh, Ken Kawaura, Hiroaki Kuno, Junji Kamai, Rika Kobayasi, Sadahumi Azukisawa, Hidekazu Kitakata, Taishi Ishisaka, Yuta Igarashi, Kumie Kodera, Tazuo Okuno, Takuro Morita, Tarou Himeno, Hiroshi Yano, Toshihiro Higashikawa, Osamu Iritani, Kunimitsu Iwai, Shigeto Morimoto, Munetaka Matoba, Masashi Okuro


A 77-year-old man who underwent radiotherapy for hepatocellular carcinoma 6 months prior consulted for esophageal obstruction. Esophagogastroduodenoscopy revealed an esophageal ulcer caused by radiotherapy for hepatocellular carcinoma. He was treated with dietary counseling and vonoprazan. After 9 months, the ulcer improved but a moderate stenosis remained. Several factors such as high fraction size, history of chemotherapy, and stress associated with food intake might involve in the development of a radiation-associated ulcer. Opportunities to choose radiotherapy for hepatocellular carcinoma may increase, so we hypothesize that esophageal ulcers might be a complication that should be noted associated with this therapy.

World J Oncol. 2021;12(2-3):67-72
doi: https://doi.org/10.14740/wjon1370


Chronic esophageal toxicity; Esophageal ulcer; Esophageal stenosis; Hepatocellular carcinoma; Radiotherapy

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