Clinical Characteristics of 130 Patients With Hepatocellular Carcinoma Followed at a Tertiary Hospital From Brazil

Andreza Correa Teixeira, Enio David Mente, Cassio Alfred Brattig Cantao, Ajith Kumar Sankarankutty, Fernanda Fernandes Souza, Tatiane Cardoso Motta, Lucas Monsignore, Jorge Elias Junior, Valdair Francisco Muglia, Daniel Giansante Abud, Fernanda Maris Peria, Sergio Zucoloto, Orlando Castro Silva, Ana de Lourdes Candolo Martinelli


Background: Hepatocellular carcinoma (HCC) is a primary malignant tumor of the liver that represents a serious public health problem all over the world, corresponding to the third cause of cancer death worldwide. The object was to present the clinical characteristics and follow-up of patients with HCC attended at the University Hospital of the Faculty of Medicine of Ribeirao Preto-USP (HCFMRP-USP), Ribeirao Preto, Sao Paulo, Brazil.

Methods: Epidemiological and clinical data were revised from medical records.

Results: A total of 130 patients participated in the study, 81.5% of them being males. Mean ( SD) age at the time of HCC diagnosis was 55.6 11.2 years. Cirrhosis was present in 89.2% of cases, with 53.4% of the patients being Child-Pugh A; chronic hepatitis B or C without cirrhosis was detected in 3.2%, non-alcoholic steatohepatitis (NASH) in 3.8%, and a normal liver in 3.8%. Orthotopic liver transplantation was performed in 26.2% of the subjects, 16.9% of the patients were submitted to surgical resection, and 6.2% to percutaneous ethanol infusion (PEI). Transarterial embolization and transarterial chemoembolization were performed in 9.2% of the patients. Systemic chemotherapy was applied to 4.6% of cases and 24.6% of the patients received symptomatic treatment.

Conclusion: Thus, in the present series cirrhosis was the main risk factor for HCC, with 53.4% of the patients being Child-Pugh A. Liver transplantation or surgical resection of the tumor, potentially curative techniques, were possible in only 43.1% of cases.

World J Oncol. 2012;3(4):165-172


Hepatocellular carcinoma; Liver Cirrhosis; Liver transplantation

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