Alpha-1 Antitrypsin Blood Levels as Indicator for the Efficacy of Cancer Treatment

Abstract

Background: Alpha-1 antitrypsin (alpha₁-AT) is a member of the serine protease inhibitors (serpins) family. Liver cells are the major source of synthesis and secretion of (alpha₁-AT) into the blood. Moreover, it has been demonstrated that alpha₁-AT is expressed and secreted by many types of malignant cells. Studies have indicated that serum levels of (alpha₁-AT) increase in a good number of malignant diseases. In addition, a significant correlation between serum levels and cancer stage has also been reported. In this work we aimed to test how _alpha1-AT levels behave at the third week after treatment with chemotherapy.

Methods: The alpha₁-AT blood levels were measured using commercially available radial immunodiffusion kit (Kent Laboratory Inc, Bellinham, Washigton) following manufacturer instructions.

Results: The alpha₁-AT blood levels were significantly decreased after treatment compared with those before the treatment started. The mean difference (before - after) treatment was 127.82 and 137.37 mg/dL with 95% CI of difference 109.06 - 146.57 and 116.08 - 158.65 mg/dL in lung and prostate cancer respectively. When we compared these levels according to the stage of cancer, we found that the mean difference (before - after) treatment was also highly significant as indicated by P-value and the 95% CI of these differences.

Conclusion: Obtained data strongly indicate the value of testing alpha₁-AT blood levels as one of the important indicators for the efficacy of cancer treatment.




World J Oncol. 2013;4(2):83-86
doi: https://doi.org/10.4021/wjon663e