World Journal of Oncology


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Kazuaki Takabe, MD, PhD, FACS
Professor, Alfiero Foundation Chair, and Clinical Chief of Breast Surgery in Department of Surgical Oncology at Roswell Park Comprehensive Cancer Center in Buffalo, New York, USA
Professor of Surgery with Tenure in Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, the State University of New York, USA

ISSN-print: 1920-4531 | ISSN-online: 1920-454X | Open Access | Bimonthly | Aims and Scope

Indexed and covered: PubMed, PubMed Central, Scopus, Elsevier Embase, Web of Science, Chemical Abstract (CA), EBSCO, Worldcat, Google, Google Scholar.

JCR Impact Factor (JIF 2022): 5.2. Q1, 47/317 (85%) Oncology (Rank by Journal Citation Indicator)

CiteScore (2022): 5; Scopus Scimago Journal Rank: 82/375 (Oncology), Q1

Journal archiving and digital preservation:


  • DNA Damage-Induced Apoptosis Suppressor Triggers Progression and Stemness of Glioma by Enhancing Lymphoid Enhancer-Binding Factor 1 Expression

    DNA damage-induced apoptosis suppressor (DDIAS) has recently been discovered to induce cancer progression, but its functions and mechanisms in glioma have not been well studied. In this study, DDIAS expression in glioma tissues was analyzed by the Gene Expression Profiling Interactive Analysis server (GEPIA) and the Gene Expression database of Normal and Tumor tissue 2 (GENT2) databases.

  • Oxygen and Iron Availability Shapes Metabolic Adaptations of Cancer Cells

    The dynamic changes between glycolysis and oxidative phosphorylation (OXPHOS) for adenosine triphosphate (ATP) output, along with glucose, glutamine, and fatty acid utilization, etc., lead to the maintenance and selection of growth advantageous to tumor cell subgroups in an environment of iron starvation and hypoxia.

  • Circadian Clock REV-ERBs Agonist SR9009 Induces Synergistic Antitumor Activity in Multiple Myeloma by Suppressing Glucose-Regulated Protein 78-Dependent Autophagy and Lipogenesis

    Proteasome inhibitors, such as bortezomib, have demonstrated efficacy in the therapeutic management of multiple myeloma (MM). However, it is important to note that these inhibitors also elicit endoplasmic reticulum stress.

  • Folfirinox vs. Gemcitabine + Nab-Paclitaxel as the First-Line Treatment for Pancreatic Cancer: A Systematic Review and Meta-Analysis

    The efficacy and safety of Folfirinox (FFX) or gemcitabine + nab-paclitaxel (GnP) to be used as the first-line drugs for pancreatic cancer (PC) is yet to be established. We conducted an analysis of retrospective studies to assess the efficacy and safety of these two regimens by comparing their survival and safety outcomes in patients with PC.

  • Update on Radiotherapy Changes of Nasopharyngeal Carcinoma Tumor Microenvironment

    The utilization of radiotherapy (RT) serves as the principal approach for managing nasopharyngeal carcinoma (NPC). Consequently, it is imperative to investigate the correlation between the radiation microenvironment and radiation resistance in NPC.







Pigs: Large Animal Preclinical Cancer Models
Pigs are playing an increasingly vital role as translational biomedical models for studying human pathophysiology. The annotation of the pig genome was a huge step forward in translatability of pigs as a biomedical model for various human diseases. Full Text

Sphingosine-1-Phosphate Inhibition Increases Endoplasmic Reticulum Stress to Enhance Oxaliplatin Sensitivity in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer resistant to current therapies, including oxaliplatin (Oxa). Growing evidence supports the ability of cancers to harness sphingolipid metabolism for survival. Full Text

Key Clinical Image

Synchronous Bilateral Breast Cancer With Discordant Receptor Status: Treating One Patient but Two Diseases
The expression of hormone receptors (estrogen and progesterone) and human epidermal growth factor receptor-2 (HER2) has been used for both therapeutic and prognostic purposes in the management of breast cancer. The presence of a discordant receptor status complicates the approach to treatment in patients with synchronous bilateral breast cancer. Full Text

Current Issue


Vol. 15, No. 2, Apr 2024

Table of Contents


Pigs: Large Animal Preclinical Cancer Models Abstract HTML PDF
Kirtan Joshi, Tejas Katam, Akshata Hegde, Jianlin Cheng, Randall S. Prather, Kristin Whitworth, Kevin Wells, Jeffrey N. Bryan, Timothy Hoffman, Bhanu P. Telugu, Jussuf T. Kaifi, Satyanarayana Rachagani 149-168

Original Article

Sphingosine-1-Phosphate Inhibition Increases Endoplasmic Reticulum Stress to Enhance Oxaliplatin Sensitivity in Pancreatic Cancer Abstract HTML PDF Suppl1
Zachary Gao, Harinarayanan Janakiraman, Yang Xiao, Sung Wook Kang, Jiangling Dong, Jasmine Choi, Besim Ogretmen, Hyun-Sung Lee, Ernest Ramsay Camp 169-180
Spinster Homologue 2 Expression Correlates With Improved Patient Survival in Hepatocellular Carcinoma Despite Association With Lymph-Angiogenesis Abstract HTML PDF
Joy Sarkar, Masanori Oshi, Vikas Satyananda, Kohei Chida, Li Yan, Aparna Maiti, Nitai Hait, Itaru Endo, Kazuaki Takabe 181-191
The Combination of Afatinib With Dasatinib or Miransertib Results in Synergistic Growth Inhibition of Stomach Cancer Cells Abstract HTML PDF
Tina Al-Janaby, Narmin Nahi, Alan Seddon, Izhar Bagwan, Said Khelwatty, Helmout Modjtahedi 192-208
DNA Damage-Induced Apoptosis Suppressor Triggers Progression and Stemness of Glioma by Enhancing Lymphoid Enhancer-Binding Factor 1 Expression Abstract HTML PDF Suppl1 Suppl2 Suppl3 Suppl4 Suppl5 Suppl6
You Lin Chen, Yi Liu, Yan Xu, An Qiang Yang, Gui Jie Chen, Jin Shan Xing, Hong Wei Su, Li Shang Liao 209-222
Predictors of Immunotherapy Efficacy in Metastatic Non-Small Cell Lung Cancer: Lung Immune Prognostic Index and Immune-Related Toxicity - ARTICLE Abstract HTML PDF
Alba Moratiel Pellitero, Maria Zapata Garcia, Marta Gascon Ruiz, Jose Miguel Arbones-Mainar, Rodrigo Lastra del Prado, Dolores Isla 223-238
Predictive Factors of Successful Double J Stent Insertion Among Advanced Cervical Cancer Patients Abstract HTML PDF
Syah Mirsya Warli, Mohd. Rhiza Z. Tala, William Saputra Wijaya 239-245
Association of Lung Cancer Risk With the Presence of Both Lung Nodules and Emphysema in a Lung Cancer Screening Trial Abstract HTML PDF Suppl1 Suppl2 Suppl3
Ya Liu, Zhuo Wei Feng, Xiao Min Liu, Hong Yuan Duan, Zhang Yan Lyu, Yu Bei Huang, Fang Fang Song, Feng Ju Song 246-256
High Ki67 Gene Expression Is Associated With Aggressive Phenotype in Hepatocellular Carcinoma Abstract HTML PDF
Vicente Ramos-Santillan, Masanori Oshi, Erek Nelson, Itaru Endo, Kazuaki Takabe 257-267
Significance of Pretreatment Hemoglobin-Albumin-Lymphocyte-Platelet Index for the Prediction of Suboptimal Surgery in Epithelial Ovarian Cancer Abstract HTML PDF PDF Suppl2
Thiti Atjimakul, Nungrutai Saeaib, Thara Tunthanathip, Paramee Thongsuksai 268-278
Incidence of Colorectal Cancer After Intestinal Infection Due to Clostridioides difficile Abstract HTML PDF
Raina K. Patel, Matthew Cardeiro, Lexi Frankel, Enoch Kim, Kazuaki Takabe, Omar M. Rashid 279-286
Lipid Profiles Impact on the Oncologic Outcome of Upper Tract Urothelial Carcinoma Abstract HTML PDF
Kuan-Yi Tu, Ching-Chia Li, Wei-Ming Li, Hsin-Chih Yeh, Hung-Lung Ke, Wen-Jeng Wu, Tsu Ming Chien, Sheng-Chen Wen, Yen-Chun Wang, Hsiang-Ying Lee 287-297
Gene Expression Profile-Guided Personalized Intraperitoneal Chemotherapy for Gastric Cancer Peritoneal Carcinomatosis Abstract HTML PDF
Vitaly A. Markovich, Sergey A. Tuzikov, Evgeny O. Rodionov, Natalia O. Popova, Matvey M. Tsyganov, Sergey V. Miller, Danil V. Podolko, Irina A. Tsydenova, Marina K. Ibragimova, Nikolai V. Litviakov 298-308
Role of Postoperative Radiotherapy on High-Risk Stage pIIIA-N2 Non-Small Cell Lung Cancer Patients After Complete Resection and Adjuvant Chemotherapy: A Retrospective Cohort Study Abstract HTML PDF
Zu Yi Chen, Huan Wei Liang, Yang Liu, Wei Huang, Xin Bin Pan 309-318

Short Communication

Characterization of Asciminib-Resistant Philadelphia Chromosome-Positive Cells Abstract HTML PDF
Seiichi Okabe, Mitsuru Moriyama, Akihiko Gotoh 319-324

Study Protocol

Empowerment-Led Guided Self-Help Intervention for Symptom Burden in Breast Cancer Women Treated With Ovarian Function Suppression: A Randomized Trial Protocol Abstract HTML PDF
Yuan Li, Yun Yun Chen, Su Xing Wang, Zheng Yue Dai, Jia Song Cui, Yu Fei Xing, Qing Wu, Qiong Fang 325-336

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World Journal of Oncology, bimonthly, ISSN 1920-4531 (print), 1920-454X (online), published by Elmer Press Inc.                     
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